Noxa mediates p18(INK4c) cell-cycle control of homeostasis in B cells and plasma cell precursors

Inhibition of Cdk4/Cdk6 by p18(INK4c) (p18) is pivotal for generation of noncycling immunoglobulin (Ig)-secreting plasma cells (PCs). In the absence of p18, CD138(+) plasmacytoid cells continue to cycle and turnover rapidly, suggesting that p18 controls PC homeostasis. We now show that p18 selective...

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Autores principales: Bretz, Jamieson, Garcia, Josefina, Huang, Xiangao, Kang, Lin, Zhang, Yang, Toellner, Kai-Michael, Chen-Kiang, Selina
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2011
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062327/
https://ncbi.nlm.nih.gov/pubmed/21163929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-06-288027
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