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Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle–coupled loss of IRF4
Dysregulation of cyclin-dependent kinase 4 (CDK4) and CDK6 by gain of function or loss of inhibition is common in human cancer, including multiple myeloma, but success in targeting CDK with broad-spectrum inhibitors has been modest. By selective and reversible inhibition of CDK4/CDK6, we have develo...
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Main Authors: | , , , , , , , , , , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
Izdano: |
American Society of Hematology
2012
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3412331/ https://ncbi.nlm.nih.gov/pubmed/22718837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-415984 |
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