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Dose Dependent Effect of Anti-CTLA-4 on Survival in Sepsis

BACKGROUND: Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) is one of the critical inhibitory regulators of early stages of T cell activation and proliferation which opposes the actions of CD28-mediated co-stimulation. Anti-CTLA-4 therapy has been effective clinically in enhancing immunity and improving s...

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Bibliografische gegevens
Hoofdauteurs: Inoue, Shigeaki, Bo, Lulong, Bian, Jinjun, Unsinger, Jacqueline, Chang, Katherine, Hotchkiss, Richard S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412306/
https://ncbi.nlm.nih.gov/pubmed/21368717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0b013e3182168cce
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