U1 snRNP Determines mRNA Length and Regulates Isoform Expression

U1 snRNP (U1), in addition to its splicing role, protects pre-mRNAs from drastic premature termination by cleavage and polyadenylation (PCPA) at cryptic polyadenylation signals (PASs) in introns. Here, a high throughput sequencing strategy of differentially expressed transcripts (HIDE-seq), mapped P...

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Autori principali: Berg, Michael G., Singh, Larry N., Younis, Ihab, Liu, Qiang, Pinto, Anna Maria, Kaida, Daisuke, Zhang, Zhenxi, Cho, Sungchan, Sherrill-Mix, Scott, Wan, Lili, Dreyfuss, Gideon
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412174/
https://ncbi.nlm.nih.gov/pubmed/22770214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.05.029
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