U1 snRNP telescripting regulates a size–function-stratified human genome

U1 snRNP (U1) functions in splicing introns and telescripting, which suppresses premature cleavage and polyadenylation (PCPA). Using U1 inhibition in human cells, we show that U1 telescripting is selectively required for sustaining long-distance transcription elongation in introns of large genes (me...

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Foilsithe in:Nat Struct Mol Biol
Main Authors: Oh, Jung-Min, Di, Chao, Venters, Christopher C, Guo, Jiannan, Arai, Chie, So, Byung Ran, Pinto, Anna Maria, Zhang, Zhenxi, Wan, Lili, Younis, Ihab, Dreyfuss, Gideon
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685549/
https://ncbi.nlm.nih.gov/pubmed/28967884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3473
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