A complex of U1 snRNP with cleavage and polyadenylation factors controls telescripting, regulating mRNA transcription in human cells

Full-length transcription in the majority of human genes depends on U1 snRNP (U1) to co-transcriptionally suppress transcription-terminating premature 3’-end cleavage and polyadenylation (PCPA) from cryptic polyadenylation signals (PASs) in introns. However, the mechanism of this U1 activity, termed...

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Veröffentlicht in:Mol Cell
Hauptverfasser: So, Byung Ran, Di, Chao, Cai, Zhiqiang, Venters, Christopher C., Guo, Jiannan, Oh, Jung-Min, Arai, Chie, Dreyfuss, Gideon
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874754/
https://ncbi.nlm.nih.gov/pubmed/31522989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.08.007
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