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Blocking SCN10A channels in heart reduces late sodium current and is antiarrhythmic
RATIONALE: While the sodium channel locus SCN10A has been implicated by genome-wide association studies as a modulator of cardiac electrophysiology, the role of its gene product Nav1.8 as a modulator of cardiac ion currents is unknown. OBJECTIVE: We determined the electrophysiological and pharmacolo...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3412150/ https://ncbi.nlm.nih.gov/pubmed/22723299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.265173 |
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