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Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice

AIMS: Female gender is a risk factor for long QT-related arrhythmias, but the underlying mechanisms remain uncertain. Here, we tested the hypothesis that gender-dependent function of the post-depolarization ‘late’ sodium current (I(Na-L)) contributes. METHODS AND RESULTS: Studies were conducted in m...

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Detalhes bibliográficos
Main Authors: Lowe, John S., Stroud, Dina Myers, Yang, Tao, Hall, Lynn, Atack, Thomas C., Roden, Dan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633400/
https://ncbi.nlm.nih.gov/pubmed/22562703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs160
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