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Multiple mechanisms underlie increased cardiac late sodium current

BACKGROUND: We recently reported a quantitative relationship between the degree of functional perturbation reported in the literature for 356 variants in the cardiac sodium channel gene SCN5A and the penetrance of resulting arrhythmia phenotypes. In the course of that work, we identified multiple SC...

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Bibliographic Details
Published in:Heart Rhythm
Main Authors: Kroncke, Brett M., Yang, Tao, Roden, Dan M.
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6655535/
https://ncbi.nlm.nih.gov/pubmed/30677491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2019.01.018
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