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Screening for Acute I(Kr) Block is Insufficient to Detect Torsades de Pointes Liability: Role of Late Sodium Current
BACKGROUND: New drugs are routinely screened for acute I(Kr) blocking properties thought to predict QT prolonging and arrhythmogenic liability. However, recent data suggest that chronic (hours) drug exposure to PI3 kinase (PI3K) inhibitors used in cancer can prolong QT by inhibiting potassium curren...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4101031/ https://ncbi.nlm.nih.gov/pubmed/24895457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.007765 |
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