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Inhibition of the α-Subunit of Phosphoinositide 3-Kinase in Heart Increases Late Sodium Current and Is Arrhythmogenic
Although inhibition of phosphoinositide 3-kinase (PI3K) is an emerging strategy in cancer therapy, we and others have reported that this action can also contribute to drug-induced QT prolongation and arrhythmias by increasing cardiac late sodium current (I(NaL)). Previous studies in mice implicate t...
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| 發表在: | J Pharmacol Exp Ther |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The American Society for Pharmacology and Experimental Therapeutics
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5931436/ https://ncbi.nlm.nih.gov/pubmed/29563327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.246157 |
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