Contrasting Nav1.8 Activity in Scn10a (−/−) Ventricular Myocytes and the Intact Heart

BACKGROUND: Genome‐wide association studies have implicated variants in SCN10A, which encodes Nav1.8, as modulators of cardiac conduction. Follow‐up work has indicated the SCN10A sequence includes an intronic enhancer for SCN5A. Yet the role of the Nav1.8 protein in the myocardium itself is still un...

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Bibliografski detalji
Izdano u:J Am Heart Assoc
Glavni autori: Stroud, Dina Myers, Yang, Tao, Bersell, Kevin, Kryshtal, Dymtro O., Nagao, Satomi, Shaffer, Christian, Short, Laura, Hall, Lynn, Atack, Thomas C., Zhang, Wei, Knollmann, Bjorn C., Baudenbacher, Franz, Roden, Dan M.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5210363/
https://ncbi.nlm.nih.gov/pubmed/27806966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002946
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