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BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines
Cross-feedback activation of MAPK and AKT pathways is implicated as a resistance mechanism for cancer therapeutic agents targeting either RAF/MEK or PI3K/AKT/mTOR. It is thus important to have a better understanding of the molecular resistance mechanisms to improve patient survival benefit from thes...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3411810/ https://ncbi.nlm.nih.gov/pubmed/22880048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042598 |
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