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BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines
Cross-feedback activation of MAPK and AKT pathways is implicated as a resistance mechanism for cancer therapeutic agents targeting either RAF/MEK or PI3K/AKT/mTOR. It is thus important to have a better understanding of the molecular resistance mechanisms to improve patient survival benefit from thes...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Public Library of Science
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3411810/ https://ncbi.nlm.nih.gov/pubmed/22880048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042598 |
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