Pluripotency markers are differentially induced by MEK inhibition in thyroid and melanoma BRAFV600E cell lines

Oncogenic mutations in BRAF are common in melanoma and thyroid carcinoma and drive constitutive activation of the MAPK pathway. Molecularly targeted therapies of this pathway improves survival compared to chemotherapy; however, responses tend to be short-lived as resistance invariably occursCell lin...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: Dorris, Emma R., Blackshields, Gordon, Sommerville, Gary, Alhashemi, Mohsen, Dias, Andrew, McEneaney, Victoria, Smyth, Paul, O'Leary, John J., Sheils, Orla
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910922/
https://ncbi.nlm.nih.gov/pubmed/26828826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2016.1139230
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