Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice

BRAF, a cellular oncogene and effector of RAS-mediated signaling, is activated by mutation in ~60% of melano-mas. Most of these mutations consist of a V600E substitution resulting in constitutive kinase activation. Mutant BRAF thus represents an important therapeutic target in melanoma. In an effort...

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Bibliografiske detaljer
Main Authors: Goel, VK, Ibrahim, N, Jiang, G, Singhal, M, Fee, S, Flotte, T, Westmoreland, S, Haluska, FS, Hinds, PW, Haluska, FG
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125533/
https://ncbi.nlm.nih.gov/pubmed/19398955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.95
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