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Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice
BRAF, a cellular oncogene and effector of RAS-mediated signaling, is activated by mutation in ~60% of melano-mas. Most of these mutations consist of a V600E substitution resulting in constitutive kinase activation. Mutant BRAF thus represents an important therapeutic target in melanoma. In an effort...
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| Glavni autori: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3125533/ https://ncbi.nlm.nih.gov/pubmed/19398955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.95 |
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