Loss of ARF sensitizes transgenic BRAF(V600E) mice to UV-induced melanoma via suppression of XPC

Both genetic mutations and ultraviolet (UV) irradiation can predispose individuals to melanoma. Although BRAF(V600E) is the most prevalent oncogene in melanoma, the BRAF(V600E) mutant is not sufficient to induce tumors in vivo. Mutation at the CDKN2A locus is another melanoma-predisposing event that...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Luo, Chi, Sheng, Jinghao, Hu, Miaofen G., Haluska, Frank G., Cui, Rutao, Xu, Zhengping, Tsichlis, Philip N., Hu, Guo-fu, Hinds, Philip W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715591/
https://ncbi.nlm.nih.gov/pubmed/23650282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4454
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados