Allele frequencies of BRAFV600 mutations in primary melanomas and matched metastases and their relevance for BRAF inhibitor therapy in metastatic melanoma

BACKGROUND: The detection of BRAFV600 mutations in patients with metastatic melanoma is important because of the availability of BRAF inhibitor therapy. However, the clinical relevance of the frequency of BRAFV600 mutant alleles is unclear. PATIENTS AND METHODS: Allele frequencies of BRAFV600 mutati...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Satzger, Imke, Marks, Lena, Kerick, Martin, Klages, Sven, Berking, Carola, Herbst, Rudolf, Völker, Bernward, Schacht, Vivien, Timmermann, Bernd, Gutzmer, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741972/
https://ncbi.nlm.nih.gov/pubmed/26498143
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