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The Proteolytic Activity of Separase in BCR-ABL-Positive Cells Is Increased by Imatinib
Separase, an endopeptidase required for the separation of sister-chromatides in mitotic anaphase, triggers centriole disengagement during centrosome duplication. In cancer, separase is frequently overexpressed, pointing to a functional role as an aneuploidy promoter associated with centrosomal ampli...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3411713/ https://ncbi.nlm.nih.gov/pubmed/22870341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042863 |
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