The Proteolytic Activity of Separase in BCR-ABL-Positive Cells Is Increased by Imatinib

Separase, an endopeptidase required for the separation of sister-chromatides in mitotic anaphase, triggers centriole disengagement during centrosome duplication. In cancer, separase is frequently overexpressed, pointing to a functional role as an aneuploidy promoter associated with centrosomal ampli...

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Autors principals: Haaß, Wiltrud, Stehle, Michael, Nittka, Stefanie, Giehl, Michelle, Schrotz-King, Petra, Fabarius, Alice, Hofmann, Wolf-Karsten, Seifarth, Wolfgang
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411713/
https://ncbi.nlm.nih.gov/pubmed/22870341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042863
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