Critical Role for Mast Cells in Interleukin-1β-Driven Skin Inflammation Associated with an Activating Nlrp3 Mutation

Cryopyrin-associated periodic syndromes (CAPS) are caused by aberrant interleukin-1β (IL-1β) production induced by NLRP3 mutations in humans, but the mechanisms involved remain poorly understood. Using a mouse model, we show a role for the indigenous microbiota and mast cells (MCs) in disease associ...

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Hauptverfasser: Nakamura, Yuumi, Franchi, Luigi, Kambe, Naotomo, Meng, Guangxun, Strober, Warren, Núñez, Gabriel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411177/
https://ncbi.nlm.nih.gov/pubmed/22819042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.04.013
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