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NLRC4-driven interleukin-1β production discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

Intestinal phagocytes transport oral antigens and promote immune tolerance, but their role in innate immune responses remains unclear. Here we report that intestinal phagocytes are anergic to Toll-like receptor ligands or commensals, but constitutively express pro-interleukin-1β (proIL-1β). Upon inf...

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Dettagli Bibliografici
Autori principali: Franchi, Luigi, Kamada, Nobuhiko, Nakamura, Yuumi, Burberry, Aaron, Kuffa, Peter, Suzuki, Shiho, Shaw, Michael H., Kim, Yun-Gi, Núñez, Gabriel
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361590/
https://ncbi.nlm.nih.gov/pubmed/22484733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2263
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