The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis

The precise mechanism by which oral infection contributes to the pathogenesis of extra-oral diseases remains unclear. Here, we report that periodontal inflammation exacerbates gut inflammation in vivo. Periodontitis leads to expansion of oral pathobionts, including Klebsiella and Enterobacter specie...

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Published in:Cell
Main Authors: Kitamoto, Sho, Nagao-Kitamoto, Hiroko, Jiao, Yizu, Gillilland, Merritt G., Hayashi, Atsushi, Imai, Jin, Sugihara, Kohei, Miyoshi, Mao, Brazil, Jennifer C., Kuffa, Peter, Hill, Brett D., Rizvi, Syed M., Wen, Fei, Bishu, Shrinivas, Inohara, Naohiro, Eaton, Kathryn A., Nusrat, Asma, Lei, Yu L., Giannobile, William V., Kamada, Nobuhiko
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414097/
https://ncbi.nlm.nih.gov/pubmed/32758418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.05.048
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