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Critical Role for Mast Cells in Interleukin-1β-Driven Skin Inflammation Associated with an Activating Nlrp3 Mutation
Cryopyrin-associated periodic syndromes (CAPS) are caused by aberrant interleukin-1β (IL-1β) production induced by NLRP3 mutations in humans, but the mechanisms involved remain poorly understood. Using a mouse model, we show a role for the indigenous microbiota and mast cells (MCs) in disease associ...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3411177/ https://ncbi.nlm.nih.gov/pubmed/22819042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.04.013 |
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