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Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C
The anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase is tightly regulated to ensure programmed proteolysis in cells. The activity of the APC/C is positively controlled by cyclin-dependent kinase (CDK), but a second level of control must also exist because phosphorylation inactivates Cdc...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3411074/ https://ncbi.nlm.nih.gov/pubmed/22713866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.168 |
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