Simple Pseudo-dipeptides with a P(2)′ Glutamate: A NOVEL INHIBITOR FAMILY OF MATRIX METALLOPROTEASES AND OTHER METZINCINS

A series of pseudo-peptides with general formula X-l-Glu-NH(2) (with X corresponding to an acyl moiety with a long aryl-alkyl side chain) have been synthesized, evaluated as inhibitors of matrix metalloproteases (MMPs), and found to display remarkable nanomolar affinity. The loss in potency associat...

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Detalhes bibliográficos
Main Authors: Devel, Laurent, Beau, Fabrice, Amoura, Mehdi, Vera, Laura, Cassar-Lajeunesse, Evelyne, Garcia, Sandra, Czarny, Bertrand, Stura, Enrico A., Dive, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411004/
https://ncbi.nlm.nih.gov/pubmed/22689580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.380782
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