Molecular Determinants of Matrix Metalloproteinase-12 Covalent Modification by a Photoaffinity Probe: INSIGHTS INTO ACTIVITY-BASED PROBE DEVELOPMENT AND CONFORMATIONAL VARIABILITY OF MATRIX METALLOPROTEINASES

Mass spectroscopy, microsequencing, and site-directed mutagenesis studies have been performed to identify in human matrix metalloelastase (hMMP-12) residues covalently modified by a photoaffinity probe, previously shown to be able to covalently label specifically the active site of matrix metallopro...

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Detalhes bibliográficos
Main Authors: Dabert-Gay, Anne-Sophie, Czarny, Bertrand, Devel, Laurent, Beau, Fabrice, Lajeunesse, Evelyne, Bregant, Sarah, Thai, Robert, Yiotakis, Athanasios, Dive, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662175/
https://ncbi.nlm.nih.gov/pubmed/18775985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805795200
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