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Complexin cross-links pre-fusion SNAREs into a zig-zag array: a structure-based model for complexin clamping

Complexin prevents SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. To understand the mechanism for this inhibition, we determined the structure of complexin bound to a mimetic of a pre-fusion SNAREpin lacking the portion of the v-SNARE which zippers last to...

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Détails bibliographiques
Auteurs principaux: Kümmel, Daniel, Krishnakumar, Shyam S., Radoff, Daniel T., Li, Feng, Giraudo, Claudio G., Pincet, Frederic, Rothman, James E., Reinisch, Karin M.
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410656/
https://ncbi.nlm.nih.gov/pubmed/21785414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2101
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