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Complexin cross-links pre-fusion SNAREs into a zig-zag array: a structure-based model for complexin clamping
Complexin prevents SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. To understand the mechanism for this inhibition, we determined the structure of complexin bound to a mimetic of a pre-fusion SNAREpin lacking the portion of the v-SNARE which zippers last to...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3410656/ https://ncbi.nlm.nih.gov/pubmed/21785414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2101 |
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