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Deamidation accelerates amyloid formation and alters amylin fiber structure

Deamidation of asparagine and glutamine is the most common non-enzymatic, post-translational modification. Deamidation can influence the structure, stability, folding, and aggregation of proteins and has been proposed to play a role in amyloid formation. However there are no structural studies of th...

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Main Authors: Dunkelberger, Emily B., Buchanan, Lauren E., Marek, Peter, Cao, Ping, Raleigh, Daniel P., Zanni, Martin T.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410046/
https://ncbi.nlm.nih.gov/pubmed/22734583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3039486
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