pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia

Retinoblastoma 1 (pRb) and the related pocket proteins, retinoblastoma-like 1 (p107) and retinoblastoma-like 2 (p130) (pRb(f), collectively), play a pivotal role in regulating eukaryotic cell cycle progression, apoptosis, and terminal differentiation. While aberrations in the pRb-signaling pathway a...

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Autors principals: Simin, Karl, Wu, Hua, Lu, Lucy, Pinkel, Dan, Albertson, Donna, Cardiff, Robert D, Dyke, Terry Van
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2004
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC340938/
https://ncbi.nlm.nih.gov/pubmed/14966529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020022
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