Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris

Optimal neuronal activity requires that supporting cells provide both efficient nutrient delivery and waste disposal. The incomplete processing of engulfed waste by their lysosomes can lead to accumulation of residual material and compromise their support of neurons. As most degradative lysosomal en...

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Main Authors: Guha, Sonia, Baltazar, Gabriel C., Tu, Leigh-Anne, Liu, Ji, Lim, Jason C., Lu, Wennan, Argall, Arthur, Boesze-Battaglia, Kathleen, Laties, Alan M., Mitchell, Claire H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408960/
https://ncbi.nlm.nih.gov/pubmed/22639870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2012.07804.x
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