Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17

Squamous cell carcinomas (SCCs) are heterogeneous and aggressive skin tumors for which innovative, targeted therapies are needed. Here, we identify a p53/TACE pathway that is negatively regulated by FOS and show that the FOS/p53/TACE axis suppresses SCC by inducing differentiation. We found that epi...

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Bibliografiske detaljer
Main Authors: Guinea-Viniegra, Juan, Zenz, Rainer, Scheuch, Harald, Jiménez, María, Bakiri, Latifa, Petzelbauer, Peter, Wagner, Erwin F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408745/
https://ncbi.nlm.nih.gov/pubmed/22772468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63103
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