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TNFα shedding and epidermal inflammation are controlled by Jun proteins
Inducible epidermal deletion of JunB and c-Jun in adult mice causes a psoriasis-like inflammatory skin disease. Increased levels of the proinflammatory cytokine TNFα play a major role in this phenotype. Here we define the underlying molecular mechanism using genetic mouse models. We show that Jun pr...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Cold Spring Harbor Laboratory Press
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2779759/ https://ncbi.nlm.nih.gov/pubmed/19933155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.543109 |
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