TNFα shedding and epidermal inflammation are controlled by Jun proteins

Inducible epidermal deletion of JunB and c-Jun in adult mice causes a psoriasis-like inflammatory skin disease. Increased levels of the proinflammatory cytokine TNFα play a major role in this phenotype. Here we define the underlying molecular mechanism using genetic mouse models. We show that Jun pr...

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Detalhes bibliográficos
Main Authors: Guinea-Viniegra, Juan, Zenz, Rainer, Scheuch, Harald, Hnisz, Denes, Holcmann, Martin, Bakiri, Latifa, Schonthaler, Helia B., Sibilia, Maria, Wagner, Erwin F.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2009
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779759/
https://ncbi.nlm.nih.gov/pubmed/19933155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.543109
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