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Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17
Squamous cell carcinomas (SCCs) are heterogeneous and aggressive skin tumors for which innovative, targeted therapies are needed. Here, we identify a p53/TACE pathway that is negatively regulated by FOS and show that the FOS/p53/TACE axis suppresses SCC by inducing differentiation. We found that epi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3408745/ https://ncbi.nlm.nih.gov/pubmed/22772468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63103 |
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