Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression

Pain and depression are frequently comorbid disorders, but the mechanism underlying this association is unknown. Here, we report that brain indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism, plays a key role in this comorbidity. We found that chronic pain in rats...

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Bibliografiske detaljer
Main Authors: Kim, Hyangin, Chen, Lucy, Lim, Grewo, Sung, Backil, Wang, Shuxing, McCabe, Michael F., Rusanescu, Gabriel, Yang, Liling, Tian, Yinghong, Mao, Jianren
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408737/
https://ncbi.nlm.nih.gov/pubmed/22751107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61884
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