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Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression
Pain and depression are frequently comorbid disorders, but the mechanism underlying this association is unknown. Here, we report that brain indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism, plays a key role in this comorbidity. We found that chronic pain in rats...
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| Hlavní autoři: | , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3408737/ https://ncbi.nlm.nih.gov/pubmed/22751107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61884 |
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