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Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression
Pain and depression are frequently comorbid disorders, but the mechanism underlying this association is unknown. Here, we report that brain indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism, plays a key role in this comorbidity. We found that chronic pain in rats...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3408737/ https://ncbi.nlm.nih.gov/pubmed/22751107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61884 |
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