TMPRSS2- Driven ERG Expression In Vivo Increases Self-Renewal and Maintains Expression in a Castration Resistant Subpopulation

Genomic rearrangements commonly occur in many types of cancers and often initiate or alter the progression of disease. Here we describe an in vivo mouse model that recapitulates the most frequent rearrangement in prostate cancer, the fusion of the promoter region of TMPRSS2 with the coding region of...

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Autors principals: Casey, Orla M., Fang, Lei, Hynes, Paul G., Abou-Kheir, Wassim G., Martin, Philip L., Tillman, Heather S., Petrovics, Gyorgy, Awwad, Hibah O., Ward, Yvona, Lake, Ross, Zhang, Luhua, Kelly, Kathleen
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408501/
https://ncbi.nlm.nih.gov/pubmed/22860005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041668
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