TMPRSS2- Driven ERG Expression In Vivo Increases Self-Renewal and Maintains Expression in a Castration Resistant Subpopulation

Genomic rearrangements commonly occur in many types of cancers and often initiate or alter the progression of disease. Here we describe an in vivo mouse model that recapitulates the most frequent rearrangement in prostate cancer, the fusion of the promoter region of TMPRSS2 with the coding region of...

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Autori principali: Casey, Orla M., Fang, Lei, Hynes, Paul G., Abou-Kheir, Wassim G., Martin, Philip L., Tillman, Heather S., Petrovics, Gyorgy, Awwad, Hibah O., Ward, Yvona, Lake, Ross, Zhang, Luhua, Kelly, Kathleen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408501/
https://ncbi.nlm.nih.gov/pubmed/22860005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041668
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