Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer

BACKGROUND: In normal prostate epithelium the TMPRSS2 gene encoding a type II serine protease is directly regulated by male hormones through the androgen receptor. In prostate cancer ERG protooncogene frequently gains hormonal control by seizing gene regulatory elements of TMPRSS2 through genomic fu...

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Autori principali: Thangapazham, Rajesh, Saenz, Francisco, Katta, Shilpa, Mohamed, Ahmed A, Tan, Shyh-Han, Petrovics, Gyorgy, Srivastava, Shiv, Dobi, Albert
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897978/
https://ncbi.nlm.nih.gov/pubmed/24418414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-16
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