Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer

BACKGROUND: In normal prostate epithelium the TMPRSS2 gene encoding a type II serine protease is directly regulated by male hormones through the androgen receptor. In prostate cancer ERG protooncogene frequently gains hormonal control by seizing gene regulatory elements of TMPRSS2 through genomic fu...

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Detalhes bibliográficos
Main Authors: Thangapazham, Rajesh, Saenz, Francisco, Katta, Shilpa, Mohamed, Ahmed A, Tan, Shyh-Han, Petrovics, Gyorgy, Srivastava, Shiv, Dobi, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897978/
https://ncbi.nlm.nih.gov/pubmed/24418414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-16
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