Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer

BACKGROUND: In normal prostate epithelium the TMPRSS2 gene encoding a type II serine protease is directly regulated by male hormones through the androgen receptor. In prostate cancer ERG protooncogene frequently gains hormonal control by seizing gene regulatory elements of TMPRSS2 through genomic fu...

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Hlavní autoři: Thangapazham, Rajesh, Saenz, Francisco, Katta, Shilpa, Mohamed, Ahmed A, Tan, Shyh-Han, Petrovics, Gyorgy, Srivastava, Shiv, Dobi, Albert
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897978/
https://ncbi.nlm.nih.gov/pubmed/24418414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-16
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