Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver

Aberrant epigenetic alterations during development may result in long-term epigenetic memory and have a permanent effect on the health of subjects. Constitutive androstane receptor (CAR; NR1I3) is a central regulator of drug/xenobiotic metabolism. Here, we report that transient neonatal activation o...

Full description

Saved in:
Bibliographic Details
Main Authors: Chen, Wei-Dong, Fu, Xianghui, Dong, Bingning, Wang, Yan-Dong, Shiah, Steven, Moore, David D., Huang, Wendong
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407349/
https://ncbi.nlm.nih.gov/pubmed/22488010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25766
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items