Activating CAR and β-Catenin Induces Uncontrolled Liver Growth and Tumorigenesis

Aberrant β-catenin activation contributes to a third or more of human hepatocellular carcinoma (HCC), but β-catenin activation alone is not sufficient to induce liver cancer in mice. Differentiated hepatocytes proliferate upon acute activation of either β-catenin or the nuclear xenobiotic receptor C...

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Udgivet i:Nat Commun
Main Authors: Dong, Bingning, Lee, Ju-Seog, Park, Yun-Yong, Yang, Feng, Xu, Ganyu, Huang, Wendong, Finegold, Milton, Moore, David D.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324535/
https://ncbi.nlm.nih.gov/pubmed/25661872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6944
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