Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

Hepatocellular carcinoma (HCC) is one of the most lethal human cancers. The search for targeted treatments has been hampered by the lack of relevant animal models for the genetically diverse subsets of HCC, including the 20-40% of HCCs that are defined by activating mutations in the gene encoding β-...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Evason, Kimberley J., Francisco, Macrina T., Juric, Vladislava, Balakrishnan, Sanjeev, Lopez Pazmino, Maria del Pilar, Gordan, John D., Kakar, Sanjay, Spitsbergen, Jan, Goga, Andrei, Stainier, Didier Y. R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489858/
https://ncbi.nlm.nih.gov/pubmed/26134322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005305
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