Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

Hepatocellular carcinoma (HCC) is one of the most lethal human cancers. The search for targeted treatments has been hampered by the lack of relevant animal models for the genetically diverse subsets of HCC, including the 20-40% of HCCs that are defined by activating mutations in the gene encoding β-...

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Vydáno v:PLoS Genet
Hlavní autoři: Evason, Kimberley J., Francisco, Macrina T., Juric, Vladislava, Balakrishnan, Sanjeev, Lopez Pazmino, Maria del Pilar, Gordan, John D., Kakar, Sanjay, Spitsbergen, Jan, Goga, Andrei, Stainier, Didier Y. R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489858/
https://ncbi.nlm.nih.gov/pubmed/26134322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005305
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