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Heterogeneous beta-catenin activation is sufficient to cause hepatocellular carcinoma in zebrafish
Up to 41% of hepatocellular carcinomas (HCCs) result from activating mutations in the CTNNB1 gene encoding β-catenin. HCC-associated CTNNB1 mutations stabilize the β-catenin protein, leading to nuclear and/or cytoplasmic localization of β-catenin and downstream activation of Wnt target genes. In pat...
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| Publicado no: | Biol Open |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6826293/ https://ncbi.nlm.nih.gov/pubmed/31575545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.047829 |
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