Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver

Aberrant epigenetic alterations during development may result in long-term epigenetic memory and have a permanent effect on the health of subjects. Constitutive androstane receptor (CAR; NR1I3) is a central regulator of drug/xenobiotic metabolism. Here, we report that transient neonatal activation o...

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Sonraí Bibleagrafaíochta
Main Authors: Chen, Wei-Dong, Fu, Xianghui, Dong, Bingning, Wang, Yan-Dong, Shiah, Steven, Moore, David D., Huang, Wendong
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407349/
https://ncbi.nlm.nih.gov/pubmed/22488010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25766
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