Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

Constitutive androstane receptor CAR (NR1I3) has been identified as a central mediator of coordinate responses to xenobiotic and endobiotic stress. Here we use leptin-deficient mice (ob/ob) and ob/ob, CAR(−/−) double mutant mice to identify a metabolic role of CAR in type 2 diabetes. Activation of C...

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Detalhes bibliográficos
Main Authors: Dong, Bingning, Saha, Pradip K., Huang, Wendong, Chen, Wenling, Abu-Elheiga, Lutfi A., Wakil, Salih J., Stevens, Robert D., Ilkayeva, Olga, Newgard, Christopher B., Chan, Lawrence, Moore, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773998/
https://ncbi.nlm.nih.gov/pubmed/19850873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909731106
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