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Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets

Malonyl-CoA, generated by acetyl-CoA carboxylases ACC1 and ACC2, is a key metabolite in the control of fatty acid synthesis and oxidation in response to dietary changes. ACC2 is associated to the mitochondria, and Acc2(-/-) mice have a normal lifespan and higher fatty acid oxidation rate and accumul...

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Bibliografski detalji
Glavni autori: Abu-Elheiga, Lutfi, Oh, Wonkeun, Kordari, Parichher, Wakil, Salih J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC193540/
https://ncbi.nlm.nih.gov/pubmed/12920182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1733877100
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