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CAR Mediates the Induction of Drug Metabolism in Mouse Models of Type 1 Diabetes
Untreated type 1 diabetes increases hepatic drug metabolism in both human patients and rodent models. We used mouse knockouts to test the role of the nuclear xenobiotic receptors CAR and PXR in this process. Streptozotocin induced diabetes resulted in increased expression of drug metabolizing cytoch...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2721020/ https://ncbi.nlm.nih.gov/pubmed/19489075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23025 |
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