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Protein Kinase Cδ Negatively Regulates Tyrosine Hydroxylase Activity and Dopamine Synthesis by Enhancing Protein Phosphatase-2A Activity in Dopaminergic Neurons

Tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine synthesis, can be regulated by phosphorylation at multiple serine residues, including serine-40. In the present study, we report a novel interaction between a key member of the novel PKC family, protein kinase Cδ (PKCδ), and TH, in whic...

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Bibliografiske detaljer
Main Authors: Zhang, Danhui, Kanthasamy, Arthi, Yang, Yongjie, Anantharam, Vellareddy, Kanthasamy, Anumantha
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407040/
https://ncbi.nlm.nih.gov/pubmed/17507557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4107-06.2007
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